Basic pharmacokinetic parameters, except the elimination half-life (T ½ ), dependent on the administered dose. After ½ hour after a single intravenous (i / v) administering 0.5 g, 1 g and 2 g in serum concentrations are 82 mg / L, 151 mg / l and 257 mg / l, respectively. After dynabolon price 2 chasa concentrations decrease, respectively, to 48 mg / l 67 mg / l and 154 mg / l. After 24 h, serum concentrations are 5 mg / l and 9 mg / l and 15 mg / l. Following intramuscular (i / m) administration at a dose of ceftriaxone of 0.5 g and 1 g of maximum concentration observed after 2 hours after injection, and comprise 38 mg / L and 81 mg / l, respectively. Bioavailability when / m administration is 100%. Repeated in / in or / m introduction observed drug accumulation in the plasma.
After the on / in or / m introduction ceftriaxone penetrates quickly into fluids and tissues in concentrations exceeding the minimum inhibitory concentration for sensitive microorganisms. In at least 24 hours after administration the concentration above MIC observed in the lung, heart, bile and bile ducts, liver, tonsils, middle ear, nasal mucosa, bones, and cerebrospinal, synovial, pleural, peritoneal fluids, and prostatic secretions. It penetrates into the cerebrospinal fluid when the meninges are inflamed. In low concentrations into breast milk. Ceftriaxone reversibly binds to plasma albumin, and binding decreases with increasing degree of concentration, reaching 95% at a concentration of antibiotic less than 25 mg / l decreasing to 85% at a concentration of 300 mg / l.
From 33% to 67% of dynabolon price the administered dose excreted by the kidneys in unchanged form. The rest is excreted unchanged in the bile, it is transformed into inactive metabolites in the gut and is excreted through the intestines. The concentrations of ceftriaxone in bile are many times higher than serum. Of ceftriaxone in adults with normal liver function and kidney is from 5.8 to 6.7 hours. Of the middle ear fluid of 25 hours. In the newborn through the kidneys derived about 70% of the administered dose. If abnormal liver function and kidney pharmacokinetics of ceftriaxone changes slightly if disrupted kidney function, increases excretion of the drug in the bile; Conversely, abnormal liver function increases the elimination through the kidneys. In patients older than 75 years, the increased by 2-3 times.
Bacterial infections caused by susceptible to dynabolon price ceftriaxone pathogens: bacterial septicemia, bacterial meningitis; abdominal infections (including peritonitis); infectious and inflammatory diseases of the gastrointestinal tract and biliary tract, including cholecystitis, cholangitis, empyema of the gall bladder), infectious and inflammatory diseases of the pelvic organs (including oophoritis, endometritis, parameters pelvioperitonit); acute otitis media; lower respiratory infections, including pneumonia, empyema, lung abscess; bone and joint infections, including infectious (septic) arthritis, osteomyelitis; skin and soft tissue infections (including infected wounds and burns); uncomplicated and complicated infections of the kidneys and urinary tract infections (acute exacerbation of chronic pyelonephritis, pyelitis);uncomplicated gonorrhea, Lyme disease.
Infectious diseases in individuals with weakened immune systems.
It is indicated for perioperative prophylaxis.