Dynabolon tablets – cephalosporin antibiotic III generation for parenteral use, has a bactericidal action, inhibits the synthesis of the cell membrane, in vitro inhibits the growth of most microorganisms. Ceftriaxone is stable to beta-lactamase enzymes (both penicillinase and cephalosporinase produced by most gram-positive and gram-negative bacteria). Effective against the following microorganisms:
Note: Many strains of dynabolon tablets these microorganisms, which in the presence of other antibiotics, such as penicillins, cephalosporins, aminoglycosides and first generations multiply resistant, susceptible to ceftriaxone. Treponema pallidum susceptible to ceftriaxone both in vitro, and in animal experiments. According to clinical data, in primary and secondary syphilis say good efficacy of ceftriaxone.
The anaerobic pathogens
Note: some of the many strains . (e.g. B. fragilis), beta-lactamase-producing resistant to ceftriaxone. To determine the sensitivity of microorganisms necessary to use discs containing ceftriaxone as shown in vitro that the classical cephalosporin defined strains of dynabolon tablets pathogens may be resistant.
For parenteral administration of ceftriaxone well penetrates the tissues and body fluids. In healthy adult subjects for ceftriaxone is characterized by long, about 8 hours, the half-life. The areas under the curve “in the serum concentration / time” after intravenous and intramuscular administration of the same. This means that the bioavailability of ceftriaxone administered intramuscularly is 100%. When intravenous ceftriaxone diffuses rapidly into the interstitial fluid, where its bactericidal activity against susceptible thereto pathogens retains for 24 hours.
Ceftriaxone is reversibly bound to albumin, and this binding is inversely proportional to the concentration of for example at a concentration in the blood serum of the drug is less than 100 mg / l ceftriaxone binding protein is 95%, and at a concentration of 300 mg / l – 85% only. Due to dynabolon tablets the lower content of albumin in the interstitial fluid ceftriaxone concentration therein is higher than in blood serum.
The half-life in healthy adult subjects is about 8 hours. In infants – to 8 days, and in the elderly over 75 years, the average half-life of approximately twice. In adults, 50-60% of ceftriaxone is excreted unchanged form in the urine, and 40-50% – in unchanged form with bile. Under the influence of the intestinal flora ceftriaxone converted into an inactive metabolite.